keywords = "arthrofibrosis, collagen, joint replacement". (1) Background: Arthrofibrosis is a common cause of patient debility and dissatisfaction after total knee arthroplasty (TKA). Many risk factors for the development of arthrofibrosis cannot be controlled by the patient or surgeon. In addition, we thank the Anna-Maria and Stephen Kellen Foundation and William and Karen Eby for their charitable contributions that enabled us to pursue this work.". The diversity of molecular pathways involved in arthrofibrosis disease progression suggest that effective treatments for arthrofibrosis may require a multimodal approach to counter the complex cellular mechanisms that direct disease pathogenesis. Manipulations under anesthesia are effective for a period of time in certain fracture patterns, and open or arthroscopic surgical debridements should be reserved for the patient for whom nonoperative modalities fail and who has a clinically significant deficit. A Drug Eluting Scaffold for the Treatment of Arthrofibrosis. Funding was provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (F32 AR068134 to E.A.L; R01 AR072597 to M.P.A. Therefore, we investigated the use of a drug scaffold for sustainable intra-articular delivery of therapeutic doses of celecoxib. @article{f39449c2fafa4430956a3dc29d0aa132. [Epub ahead of print] Molecular landscape of arthrofibrosis: Microarray and bioinformatic analysis of the temporal expression of 380 genes during contracture genesis. The treatment of Arthrofibrosis requires very specialized care and there are only a handful of orthopedic surgeons in the world who have a … note = "Funding Information: We thank members of the orthopedic research laboratories and especially Afton K. Limberg, BS, Meagan E. Tibbo, MD, Amel Dudakovic, PhD, and Roman Thaler, PhD, for their expertise and guidance. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. journal = "Tissue Engineering - Part C: Methods", https://doi.org/10.1089/ten.tec.2018.0136. 33, 34. Introduction: The inflammatory cascade and production of prostaglandins may play a role in the pathogenesis of arthrofibrosis, a debilitating condition after joint replacement and other orthopedic procedures. The nonsteroidal anti-inflammatory drug, celecoxib, may have therapeutic benefits for arthrofibrosis, but current methods for its local delivery (e.g., biologically derived microspheres) are not translatable to immediate clinical use. I have been massaging at home, using a hand held massager and roller. This association and the symptoms separate it from s… N2 - Arthrofibrosis after periarticular fractures can create clinically significant impairments in both the upper and lower extremities. Therefore, we investigated the use of a drug scaffold for sustainable intra-articular delivery of therapeutic doses of celecoxib. Synovitis occurs when the membrane that lubricates and protects the bones from friction damage becomes inflamed. (1) Background: Arthrofibrosis is a common cause of patient debility and dissatisfaction after total knee arthroplasty (TKA). First, a lack of an ability to straighten ones knee out is a flexion contracture. Early postoperative motion should be promoted whenever possible. Materials and Methods: Celecoxib was eluted from clinically approved biodegradable collagen membranes over 7 days as measured by UV spectroscopy and high-performance liquid chromatography/mass spectroscopy. ... (IRB) protocol (Mayo Clinic Rochester IRB #09–000115) prior to enrollment. Stutzman.Jessica@mayo.edu title = "A Drug Eluting Scaffold for the Treatment of Arthrofibrosis". 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